Large scientific reviews and cohort studies suggest that people with blood group O generally have a lower risk of developing certain cancers compared with non-O groups (A, B, AB). One meta-analysis summarized it clearly: “Blood group A is associated with increased risk of cancer, and blood group O is associated with decreased risk.”
For specific cancers, the pattern appears most consistent with stomach and pancreatic cancers. Studies show that people with blood group A or AB face a higher risk of gastric cancer than those with blood group O. Similarly, pancreatic cancer risk tends to be greater among non-O blood types.
In some populations, other findings vary. For instance, a study of Chinese men found that blood group B had a lower risk of gastrointestinal cancers than group A, highlighting how results can differ by region and genetics.
Overall, blood group O appears to offer the lowest relative cancer risk across many cancer types, although the differences are modest. One analysis estimated that people with blood group A had about a 19 percent higher risk of stomach cancer compared to group O.
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